ST. LOUIS--(BUSINESS WIRE)--Pharsight, a market-leading provider of software and scientific consulting services to improve productivity and decision-making in clinical drug development, announced today that it has launched the Phoenix Pharmacometric Productivity Challenge, a competition to recognize excellence in the application of pharmacometric software to critical problems in drug development.

Certara’s latest release of Phoenix 8.2, the industry gold standard in PK/PK software, introduces new capabilities that support our commitment to customer feedback to deliver faster performance, an enhanced user interface, and greater ease of use to our customers. Certara’s latest release of Phoenix 8.2, the industry gold standard in PK/PK software, introduces new capabilities that support our commitment to customer feedback to deliver faster performance, an enhanced user interface, and greater ease of use to our customers. The document templates and automated scripts in Phoenix WinNonlin Validation Suite 4.0 have been updated to reflect the new functionality in Phoenix WinNonlin 6.4. Phoenix WinNonlin is part of the premier Phoenix PK/PD software platform used by more than 5,000 biopharmaceutical companies, veterinary and academic researchers, along with the FDA. The document templates and automated scripts in Phoenix WinNonlin Validation Suite 4.0 have been updated to reflect the new functionality in Phoenix WinNonlin 6.4. Phoenix WinNonlin is part of the premier Phoenix PK/PD software platform used by more than 5,000 biopharmaceutical companies, veterinary and academic researchers, along with the FDA. Bundle Cost - $1,500 ($750 Academia) Certara University offers a bundle of five e-learning courses to prepare you to be certified as a Phoenix Certified NCA Analyst. This bundle includes 5 relevant courses updated with the latest version of Phoenix WinNonlin, and two certification exams.

The Phoenix Pharmacometric Productivity Challenge seeks to promote the value of population-based pharmacometric software in industry, to encourage pharmacometric software productivity, and to enhance awareness of, and interest in, the role of pharmacometrics in commercial drug development.

Challenge entries will be evaluated based on innovative, leading-edge uses of pharmacometric toolkits on Phoenix^®, Pharsight’s desktop software platform for pharmacokinetic and pharmacodynamic (PK/PD) data analysis and modeling. Entries may include a pharmacometric workflow, a model development or fitting technique, a model validation method implemented using Phoenix, or novel use of other Phoenix-based software applications.

Pharsight is now accepting submissions from industry and academia for the inaugural 2011 Phoenix Pharmacometric Productivity Challenge. The winning submission will be announced at the American Conference on Pharmacometrics (ACoP) to be held April 4-7, 2011 in San Diego, California. More information about the 2011 Phoenix Pharmacometric Productivity Challenge is available at www.pharsight.com/phoenix_challenge.php.

“The interdisciplinary field of pharmacometrics continues to mature and demonstrate tangible impact on drug development and regulatory decisions,” said Daniel Weiner, Ph.D., Senior Vice President and Chief Technology Officer of Pharsight. “As part of its ongoing mission to provide leading modeling and simulation tools to tomorrow’s pharmacometrics practitioners, Pharsight is pleased to commence the Phoenix Pharmacometric Productivity Challenge. We are also pleased to include distinguished academic leaders from Pharsight’s Phoenix Centers of Excellence Program in our panel of judges for the Phoenix Challenge, and look forward to receiving submissions from academic and industry colleagues.”

About Phoenix

Phoenix is Pharsight's desktop software platform that supports model-based drug development and its utility in translational science. Phoenix^® WinNonlin^® is the next generation of Pharsight’s industry standard software for PK/PD modeling and noncompartmental analysis. Phoenix^® NLME™ provides powerful new data processing and modeling tools for population PK/PD analysis. Phoenix^® Connect™ integrates applications built on the Phoenix platform with commonly used third-party analysis and modeling tools such as NONMEM^®, R^®, SAS^® and S-PLUS^®.

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About Pharsight

Pharsight, a Certara™ company, is a market-leading provider of software products and scientific consulting services to help pharmaceutical and biotechnology companies improve their drug development process, regulatory compliance and strategic decision-making. Established in 1995, the company’s goal is to help customers reduce the time, cost and risk of drug development, as well as optimize the post-approval marketing and use of pharmaceutical products. Headquartered in St. Louis, Missouri, with more than 1200 customers worldwide, Pharsight products and services are used by all of the world’s top 50 pharmaceutical firms. More information about Pharsight is available at www.pharsight.com.

About Certara

Certara is dedicated to improving human health through a broad spectrum of products and services, from molecular discovery to clinical research. Formed in 2008, Certara unites Tripos and Pharsight Corporation. More information about Certara is available at www.certara.com.

Registered Trademarks and Trademarks

Pharsight, Phoenix, Phoenix WinNonlin, Phoenix NLME, Phoenix Connect and Certara are trademarks or registered trademarks of Tripos, L.P. All other brands and product names are trademarks or registered trademarks of their respective holders.

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The gold standard software in Population Pharmacokinetic and Pharmacokinetic-Pharmacodynamic modelling

The software consists of three parts:

NONMEM^® itself, the basic and very general nonlinear regression programme.
PREDPP - a powerful package of subroutines handling population PK data as well as general linear and nonlinear models, which can free the user from coding standard knetic type equations while simultaneously allowing complicated patient-type data to be easily analysed.
NM-TRAN - a preprocessor allowing control and other needed inputs to be specified in a user-friendly manner. Both NONMEM and NM-TRAN are batch type programmes.

NONMEM® 7.5

The latest release of NONMEM^® includes these enhancements and more.

1. Population analysis methods available for handling a variety of PK/PD population analysis problems:

First Order Conditional Estimation (FOCE)
Laplace Conditional Estimation
Iterative Two Stage (ITS)
Importance Sampling Expectation-Maximization (IMP)
Stochastic Approximation Expectation-Maximization (SAEM)
Markov-Chain Monte Carlo Bayesian Analysis (BAYES, NUTS)

2. Parallel computing of a single problem over multiple cores or computers, for estimation, covariance assessment, simulation, nonparametric analysis and posthoc parameter and weighted residual diagnostic evaluation, significantly reducing completion time

3. Increased efficiency of dynamic memory allocation to handle very large problems, eliminating the need to recompile the NONMEM® program for unusually large problems

Additional features, some new to NONMEM 7.5, include:

Model multiple mixed effects levels, with random effects across groups of individuals such as clinical site
Solve ordinary differential equations (ODE) and differential algebraic equations (DAE) with algorithms such as LSODA, LSODI1, CVODES and IDAS
Solve delay differential equations (DDE) with algorithms such as RADAR5 (for stiff equations) and D

Phoenix Winnonlin Software Cost